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Unfortunately liver cirrhosis cannot be reversed. This is a late-stage result of liver disease. The Stages Of Liver Disease American Liver Foundation The structure of the scar tissue has created a risk of rupture within the liver. Stage four liver disease . Liver transplant is the only treatment for this stage of the disease and has the potential to extend a persons life by five years or more states UCSF. It is the final common route in the evolution of multiple liver pathologies whose last stage is cirrhosis. Understanding Hepatitis C from Diagnosis to Stage 4 End-Stage Liver Disease Medically reviewed by Judith Marcin MD. There are two stages in cirrhosis. Symptoms of stage 4 liver disease include vomiting diarrhea and fatigue caused by reduced blood flow due to permanent liver scarring. Reactions to medications street drugs or toxic chemicals. Cirrhosis of the liver stage 4 can result in severe health complications such as portal hypertension spleen enlargement...